FORCE FIELD DRIVEN MOLECULAR DYNAMICS:

11/11/97
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Table of Contents

MOLECULAR DYNAMICS

A. BASIS OF FORCE FIELD DRIVEN MOLECULAR DYNAMICS:

calculating new position

integration problem

delta t must be very small

General comments

The accuracy of the trajectory

Improvements...

1) Leap-frog (Verlet, 1967) Integration

PAC Integration (Harrison, 1993)

2) Non-bonded cutoff

3) Infrequent list updates (for non-bondeds)

4) The SHAKE Algorithm (van Gunsteren & Berendsen, 1977)

Improvements for accuracy. 1)Smoothing

for examples

2) Solvation

Choices, choices, choices…

B. Getting Started.

Applying the velocities

2) EQUILIBRATION

C. Different Types of MD Runs

nVE = constant

nVT = constant (two approaches)

the current temperature

nPH = constant

References

Author: John E. Wampler

M.D. References